Running pip install pwntools directly will fail. You need to install cmake and pkg-config first, and resolve the unicorn compilation error by manually installing unicorn from the corresponding version’s repository source:

brew install cmake pkg-config
pip install "git+https://github.com/unicorn-engine/unicorn@d568885d64c89db5b9a722f0c1bef05aa92f84ca#subdirectory=bindings/python/"
pip install pwntools

As pwntools gets updated, its unicorn dependency version will change. You’ll need to replace the commit hash with the one corresponding to the required version tag.